Distala tubuli funktion
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Distal convoluted tubule
Feature of kidney anatomy
The distal convoluted tubule (DCT) is a portion of kidneynephron between the loop of Henle and the collecting tubule.
Physiology
[edit]It is partly responsible for the regulation of potassium, sodium, calcium, and pH.
On its apical surface (lumen side), cells of the DCT have a thiazide-sensitive Na-Cl cotransporter and are permeable to Ca, via the TRPV5 channel. On the basolateral surface (peritubular capillary side) there is an ATP-dependent Na/K antiporter pump, a secondary active Na/Ca transporter, and an ATP dependent Ca transporter. The basolateral ATP dependent Na/K pump produces the gradient for Na to be absorbed from the apical surface via the Na/Cl symporter, and for Ca to be reclaimed into the blood by the Na/Ca basolateral antiporter.
- It regulates pH by absorbing bicarbonate and secreting protons (H+) into the filtrate, or by absorbing protons and secreting bicarbonate into the filtrate.
- Sodium and potassium levels are controlled by secreting K+ and absorbing Na+. Sodium absorption by the distal tubule is mediated by the hormonealdosterone. Aldosterone increases sodium reabsorption. Sodium and
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What is the function of the distal convoluted tubule in kidney physiology?
The distal convoluted tubule plays a crucial role in reabsorbing sodium, calcium, and chloride ions while secreting potassium and hydrogen ions, helping to regulate electrolyte balance, pH, and blood pressure. It is also involved in fine-tuning the osmolarity of urine, contributing to the kidney’s ability to concentrate urine.
Where is the distal convoluted tubule located within the nephron structure?
The distal convoluted tubule is located in the nephron within the kidney, following the loop of Henle and preceding the collecting duct.
How does the distal convoluted tubule contribute to electrolyte balance in the body?
The distal convoluted tubule contributes to electrolyte balance by reabsorbing sodium and chloride ions while secreting potassium and hydrogen ions. It is influenced by hormones like aldosterone, which increases sodium reabsorption and potassium excretion, and parathyroid hormone, which regulates calcium and phosphate reabsorption.
How does the distal convoluted tubule affect blood pressure regulation?
The distal convoluted tubule helps regulate blood pressure by reabsorbing sodium a
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Tubuli
Tubuli eller tubulussystemet är en rörsystem inom njurarna. vid utsidan från tubuli finns tättsittande cellager,och längst ut på varenda rör sitter Bowmans kapsel. Primärurinen går genom tubuli i delen som kallas proximal tubuli, innan urinen övergår inom Henles slynga som består av rör; denna existerar en struktur i njurarnasnefron där vätska reabsorberas ur primärurinen. Därmed koncentreras urinens innehåll från främst urea men även andra slaggprodukter såsom galla pigment vilket ger urinen dess gulaktiga färg.
Efter Henles slynga färdas primärurinen mot distala tubuli varefter tubuli mynnar ut i en rör likt samlar upp urinen.
Tubuli är även en sektion av sekretionen, vilket betyder att den kan sänka koncentrationen från ett tema i kroppen eller utföra sig från med främmande ämnen. Urinen som går via tubuli förs antingen ut tillsammans med urinen alternativt återupptas.